Heracleum moellendorffii roots inhibit the production of pro-inflammatory mediators through the inhibition of NF-κB and MAPK signaling, and activation of ROS/Nrf2/HO-1 signaling in LPS-stimulated RAW264.7 cells

• Main Authors: Ha Na Kim (Author), Jeong Dong Kim (Author), Joo Ho Yeo (Author), Ho-Jun Son (Author), Su Bin Park (Author), Gwang Hun Park (Author), Hyun Ji Eo (Author), Jin Boo Jeong (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Heracleum moellendorffii roots (HM-R) have been long treated for inflammatory diseases such as arthritis, backache and fever. However, an anti-inflammatory effect and the specific mechanism of HM-R were not yet clear. In this study, we for the first time explored the anti-inflamm...