Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent

• المؤلفون الرئيسيون: Ahmed M. Abdelaal (مؤلف), Ikjot S. Sohal (مؤلف), Shreyas G. Iyer (مؤلف), Kasireddy Sudarshan (مؤلف), Esteban A. Orellana (مؤلف), Kenan E. Ozcan (مؤلف), Andrea P. dos Santos (مؤلف), Philip S. Low (مؤلف), Andrea L. Kasinski (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2024-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Use of tumor-suppressive microRNAs (miRNAs) as anti-cancer agents is hindered by the lack of effective delivery vehicles, entrapment of the miRNA within endocytic compartments, and rapid degradation of miRNA by nucleases. To address these issues, we developed a miRNA delivery strategy that includes...