Fexinidazole: a potential new drug candidate for Chagas disease.

• Main Authors: Maria Terezinha Bahia (Author), Isabel Mayer de Andrade (Author), Tassiane Assíria Fontes Martins (Author), Álvaro Fernando da Silva do Nascimento (Author), Lívia de Figueiredo Diniz (Author), Ivo Santana Caldas (Author), André Talvani (Author), Bernadette Bourdin Trunz (Author), Els Torreele (Author), Isabela Ribeiro (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: New safe and effective treatments for Chagas disease (CD) are urgently needed. Current chemotherapy options for CD have significant limitations, including failure to uniformly achieve parasitological cure or prevent the chronic phase of CD, and safety and tolerability concerns. Fexinidaz...