Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

• Main Authors: Kevin J. H. Allen (Author), Ohyun Kwon (Author), Matthew R. Hutcheson (Author), Joseph J. Grudzinski (Author), Stuart M. Cain (Author), Frederic A. Cruz (Author), Remitha M. Vinayakamoorthy (Author), Ying S. Sun (Author), Lindsay Fairley (Author), Chandra B. Prabaharan (Author), Ryan Dickinson (Author), Valerie MacDonald-Dickinson (Author), Maruti Uppalapati (Author), Bryan P. Bednarz (Author), Ekaterina Dadachova (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we examine the dosimetry in beagle dogs and cross-reacti...