HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer

• Main Authors: Dessislava N. Mladenova (Author), Jane E. Dahlstrom (Author), Phuong N. Tran (Author), Fahad Benthani (Author), Elaine G. Bean (Author), Irvin Ng (Author), Laurent Pangon (Author), Nicola Currey (Author), Maija R. J. Kohonen-Corish (Author)
• Format: Book
• Published: The Company of Biologists, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative re...