CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti.

• Main Authors: Sabino Pacheco (Author), Adrián S Gallegos (Author), Ángel E Peláez-Aguilar (Author), Jorge Sánchez (Author), Isabel Gómez (Author), Mario Soberón (Author), Alejandra Bravo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Aedes aegypti cadherin-like protein (Aae-Cad) and the membrane-bound alkaline phosphatase (Aae-mALP) are membrane proteins identified as putative receptors for the larvicidal Cry toxins produced by Bacillus thuringiensis subsp. israelensis bacteria. Cry toxins are the most used toxins in the con...