Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

• Main Authors: Mohammed Farrag El-Behairy (Author), Walaa Hamada Abd-Allah (Author), Mohamed M. Khalifa (Author), Mohamed S. Nafie (Author), Mohamed A. Saleh (Author), Mohammed S. Abdel-Maksoud (Author), Tarfah Al-Warhi (Author), Wagdy M. Eldehna (Author), Ahmed A. Al‐Karmalawy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin's pharmacophoric features. The anti-proliferative activity was evaluated at the NCI against a panel of 60 cancer...