Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

• Main Authors: Veronika Voronova (Author), Victor Sokolov (Author), Yannick Morias (Author), Malin Jonsson Boezelman (Author), Maria Wågberg (Author), Marcus Henricsson (Author), Karl Hansson (Author), Alexey Goltsov (Author), Kirill Peskov (Author), Monika Sundqvist (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to reduce cardiac BCAA levels and demonstrated positiv...