Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS)

• Main Authors: Nils Krueger (Author), Klaus Weber (Author), Nils Warfving (Author), Alex Vitali (Author), Jürgen Nolde (Author), Tobias B. Schuster (Author), Gustav Gerd Bruer (Author), Otto Creutzenberg (Author), Benno Wessely (Author), Michael Stintz (Author), Valerie Moise (Author), Marco Kellert (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The aim of the present study was to understand the mechanism of lethality associated with high dose inhalation of a low-density hydrophobic surface-treated SAS observed in some acute inhalation studies. It was demonstrated that physical obstruction of the upper respiratory tract (nasal cavities) cau...