Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activ...
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Elsevier,
2017-01-01T00:00:00Z.
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