Endogenous and Exogenous Glucocorticoids Prevent Trimethyltin From Causing Neuronal Degeneration of the Mouse Brain In vivo: Involvement of Oxidative Stress Pathways

• Main Authors: Makoto Shuto (Author), Kei Higuchi (Author), Chie Sugiyama (Author), Masanori Yoneyama (Author), Nobuyuki Kuramoto (Author), Reiko Nagashima (Author), Koichi Kawada (Author), Kiyokazu Ogita (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy. However, no evaluation has been attempted to determine the mechanism underlying the enhancement of TM...