CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody

• Main Authors: Cristina Melero (Author), S. Jimmy Budiardjo (Author), Anahita Daruwalla (Author), Lance Larrabee (Author), Oleg Ganichkin (Author), Alexander J. Heiler (Author), Jill Fenaux (Author), Ben Chung (Author), Germaine Fuh (Author), Yao-Ming Huang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. Blockade of CD200R1-dependent signaling enhances T cell-mediated antitumor activity in vitro and in vivo. 23ME-0...