CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody

• প্রধান লেখক: Cristina Melero (লেখক), S. Jimmy Budiardjo (লেখক), Anahita Daruwalla (লেখক), Lance Larrabee (লেখক), Oleg Ganichkin (লেখক), Alexander J. Heiler (লেখক), Jill Fenaux (লেখক), Ben Chung (লেখক), Germaine Fuh (লেখক), Yao-Ming Huang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. Blockade of CD200R1-dependent signaling enhances T cell-mediated antitumor activity in vitro and in vivo. 23ME-0...