A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation

• Κύριοι συγγραφείς: Matthew J. Winter (Συγγραφέας), Yosuke Ono (Συγγραφέας), Jonathan S. Ball (Συγγραφέας), Anna Walentinsson (Συγγραφέας), Erik Michaelsson (Συγγραφέας), Anna Tochwin (Συγγραφέας), Steffen Scholpp (Συγγραφέας), Charles R. Tyler (Συγγραφέας), Steve Rees (Συγγραφέας), Malcolm J Hetheridge (Συγγραφέας), Mohammad Bohlooly-Y (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potential genetic contributing factors. The complex aetiol...