A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation

A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation

The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potential genetic contributing factors. The complex aetiol...

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Main Authors: Matthew J. Winter (Author), Yosuke Ono (Author), Jonathan S. Ball (Author), Anna Walentinsson (Author), Erik Michaelsson (Author), Anna Tochwin (Author), Steffen Scholpp (Author), Charles R. Tyler (Author), Steve Rees (Author), Malcolm J Hetheridge (Author), Mohammad Bohlooly-Y (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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3rd Floor Main Library

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