A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation

• Main Authors: Matthew J. Winter (Author), Yosuke Ono (Author), Jonathan S. Ball (Author), Anna Walentinsson (Author), Erik Michaelsson (Author), Anna Tochwin (Author), Steffen Scholpp (Author), Charles R. Tyler (Author), Steve Rees (Author), Malcolm J Hetheridge (Author), Mohammad Bohlooly-Y (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potential genetic contributing factors. The complex aetiol...