Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity

• Main Authors: Yuri Svirkin (Author), Jaeweon Lee (Author), Richard Marx (Author), Seongkyu Yoon (Author), Nelson Landrau (Author), Md Abul Kaisar (Author), Bin Qin (Author), Jin H. Park (Author), Khondoker Alam (Author), Darby Kozak (Author), Yan Wang (Author), Xiaoming Xu (Author), Jiwen Zheng (Author), Benjamin Rivnay (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amphotericin B (AmB) is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections. Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer, which heat treatment (curing) modifies. Although...