Physiologically‐based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate

• Main Authors: Walaa Y. B. Mahdy (Author), Kazuhiro Yamamoto (Author), Takahiro Ito (Author), Naoko Fujiwara (Author), Kazumichi Fujioka (Author), Tadasu Horai (Author), Ikuo Otsuka (Author), Hitomi Imafuku (Author), Tomohiro Omura (Author), Kazumoto Iijima (Author), Ikuko Yano (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study aimed to determine the effects of pregnancy and ontogeny on risperidone and paliperidone pharmacokinetics by assessing their serum concentrations in two subjects and constructing a customized physiologically‐based pharmacokinetic (PBPK) model. Risperidone and paliperidone serum c...