Dose‐dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin

• Main Authors: Nicolas Hohmann (Author), Anna S. Friedrichs (Author), Jürgen Burhenne (Author), Antje Blank (Author), Gerd Mikus (Author), Walter E. Haefeli (Author)
• 格式: 圖書
• 出版: Wiley, 2024-08-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract The dose dependence of the effect of enzyme inducers and the effect of the combined administration of two inducers that exert their effect via the same induction pathway (pregnane X receptor) have not been well studied. Using oral midazolam microdoses (30 μg), we have investigated CYP3A4 in...