Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors

• Main Authors: Jin Chen (Author), Lingjun Zhang (Author), Maojing Yang (Author), Elizabeth D. Hughes (Author), Zachary T. Freeman (Author), Thomas L. Saunders (Author), Feng Lin (Author)
• Format: Book
• Published: Karger Publishers, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use. However, most, if not all, C3 inhibitors are human or non-human primate C3-specific, making e...