Inhibition of myostatin improves muscle atrophy in oculopharyngeal muscular dystrophy (OPMD)

• Main Authors: Pradeep Harish (Author), Alberto Malerba (Author), Ngoc Lu‐Nguyen (Author), Leysa Forrest (Author), Ornella Cappellari (Author), Fanny Roth (Author), Capucine Trollet (Author), Linda Popplewell (Author), George Dickson (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oculopharyngeal muscular dystrophy (OPMD) is a late‐onset muscle disease affecting one per 80 000 of the general population characterized by profound dysphagia and ptosis, and limb weakness at later stages. Affected muscles are characterized by increased fibrosis and atrophy. Myo...