Lack of rewarding effects of a soluble epoxide hydrolase inhibitor TPPU in mice: Comparison with morphine

• Main Authors: Xiayun Wan (Author), Yuko Fujita (Author), Lijia Chang (Author), Yan Wei (Author), Li Ma (Author), Gerile Wuyun (Author), Yaoyu Pu (Author), Bruce D. Hammock (Author), Kenji Hashimoto (Author)
• Format: Book
• Published: Wiley, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim Although opioids have been used as treatment of neuropathic pain, opioids have abuse potential in humans. Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neur...