An integrated analysis of the structural changes and gene expression of spleen in human visceral leishmaniasis with and without HIV coinfection.

• Main Authors: Jonathan L M Fontes (Author), Ricardo Khouri (Author), Luis Gustavo C Reinaldo (Author), Erina M A Hassegawa (Author), Antônio José Meneses Filho (Author), Caroline V B de Melo (Author), Pablo Ivan P Ramos (Author), Rafael de Deus Moura (Author), Carla Pagliari (Author), Marta Santos (Author), Raimundo José C Araújo (Author), Johan Van Weyenbergh (Author), Luiz A R de Freitas (Author), Carlos Henrique N Costa (Author), Washington L C Dos-Santos (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The spleen plays a pivotal role in the pathogenesis of visceral leishmaniasis. In severe forms of the disease, the spleen undergoes changes that can compromise its function in surveilling blood-circulating pathogens. In this study, we present an integrated analysis of the structural and gene express...