Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

• Main Authors: Yang Liu (Author), Xiaojia Liu (Author), Na Zhang (Author), Mingxiao Yin (Author), Jingwen Dong (Author), Qingxuan Zeng (Author), Genxiang Mao (Author), Danqing Song (Author), Lu Liu (Author), Hongbin Deng (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blocking therapy has become a major pillar of cancer immunotherapy. Compared with antibodies targeting, small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed. Here we identified berberine (...