Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study

• Main Authors: Seyed Hamidreza Mirabutalebi (Author), Noorodin Karami (Author), Hamid Reza Ashrafzadeh (Author), Zhima Akhvansales (Author), Maryam Tavakoli (Author), Nasrin Ghasemi (Author)
• Format: Book
• Published: Shahid Sadoughi University of Medical Sciences, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The quality of oocyte is often considered as a limiting factor for fertility, especially IVF. Some mitochondrial mutations, particularly the 4977-bp deletion increase with the age. Thus, this mutation can serve as a marker for cell aging, which indicates the reduced quality of the oocyte...