QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition

• Main Authors: Robert Ancuceanu (Author), Patriciu Constantin Popovici (Author), Doina Drăgănescu (Author), Ștefan Busnatu (Author), Beatrice Elena Lascu (Author), Mihaela Dinu (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objectives: HMG-CoA reductase is an enzyme that regulates the initial stage of cholesterol synthesis, and its inhibitors are widely used in the treatment of cardiovascular diseases. Methods: We have created a set of quantitative structure-activity relationship (QSAR) models for human HMG-...