Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa

• Main Authors: Hikaru Takano (Author), Tomoyuki Shibata (Author), Masakatsu Nakamura (Author), Naoko Sakurai (Author), Tasuku Hayashi (Author), Masafumi Ota (Author), Tomoe Nomura-Horita (Author), Ranji Hayashi (Author), Takeo Shimasaki (Author), Toshimi Otsuka (Author), Tomomitsu Tahara (Author), Tomiyasu Arisawa (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background CpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation is clinically important for predicting cancer development. DNA methyltransferase (DNMT) 3a is considered to play critical roles in the DNA me...