Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

• Główni autorzy: Lamya H. Al-Wahaibi (Autor), Mohamed A. Mahmoud (Autor), Yaser A. Mostafa (Autor), Ali E. Raslan (Autor), Bahaa G. M. Youssif (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib. Hybrids VIc, VIf, VIg, VIi, and VIk have the highest antiproliferative activity. Co...