Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib. Hybrids VIc, VIf, VIg, VIi, and VIk have the highest antiproliferative activity. Co...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi (Author), Mohamed A. Mahmoud (Author), Yaser A. Mostafa (Author), Ali E. Raslan (Author), Bahaa G. M. Youssif (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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3rd Floor Main Library

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