Identification of potential inhibitors for drug-resistant EGFR mutations in non-small cell lung cancer using whole exome sequencing data

• Main Authors: Nagasundaram Nagarajan (Author), Chittibabu Guda (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Epidermal growth factor receptor (EGFR) gene mutations are prevalent in about 50% of lung adenocarcinoma patients. Highly effective tyrosine kinase inhibitors (TKIs) targeting the EGFR protein have revolutionized treatment for the prevalent and aggressive lung malignancy. However, the emergence of n...