Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma

• Main Authors: Ping Hu (Author), Haiqing Isaac Dai (Author), James Bourdage (Author), Dongli Zhou (Author), Ky Trang (Author), Karey Kowalski (Author), Carlo Bello (Author), Jennifer Hibma (Author), Akash Khandelwal (Author), Kyra Cowan (Author), Jennifer Dong (Author), Karthik Venkatakrishnan (Author), Wei Gao (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Like other monoclonal antibodies, immune checkpoint inhibitors may be immunogenic in some patients, potentially affecting pharmacokinetics (PKs) and clinical outcomes. In post hoc analyses, we characterized antidrug antibody (ADA) development with avelumab monotherapy in patients with metas...