Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.

• Main Authors: Frédéric-Antoine Dauchy (Author), Mélanie Bonhivers (Author), Nicolas Landrein (Author), Denis Dacheux (Author), Pierrette Courtois (Author), Florian Lauruol (Author), Sylvie Daulouède (Author), Philippe Vincendeau (Author), Derrick R Robinson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei gambiense is the main causative agent of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Because of limited alternatives and treatment toxicities, new therapeutic options are urgently needed for patients with HAT. Sterol 14alpha-demethylase (CYP51) is a poten...