Transcriptomic Profiling in Mice With CB1 receptor Deletion in Primary Sensory Neurons Suggests New Analgesic Targets for Neuropathic Pain

• Main Authors: Yongmin Liu (Author), Min Jia (Author), Caihua Wu (Author), Hong Zhang (Author), Chao Chen (Author), Wenqiang Ge (Author), Kexing Wan (Author), Yuye Lan (Author), Shiya Liu (Author), Yuanheng Li (Author), Mengyue Fang (Author), Jiexi He (Author), Hui-Lin Pan (Author), Jun-Qiang Si (Author), Man Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 1 and type 2 cannabinoid receptors (CB1 and CB2, respectively) mediate cannabinoid-induced analgesia. Loss of endogenous CB1 is associated with hyperalgesia. However, the downstream targets affected by ablation of CB1 in primary sensory neurons remain unknown. In the present study, we hypothesi...