Influence of cytochrome P450 2D6*10/*10 genotype on the risk for tramadol associated adverse effects: a retrospective cohort study

• Main Authors: Mahmood Mahajna (Author), Rami Abu Fanne (Author), Mahmoud Odeh (Author), Matitiahu Berkovitch (Author), Elias Tannous (Author), Sara Eyal (Author), Shlomo Vinker (Author), Ilan Green (Author), Ilan Matok (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tramadol is primarily metabolized by the highly polymorphic CYP2D6 enzyme, leading to a large spectrum of adverse events and clinical response. Ample evidence pointed a reduced CYPD26 activity score in individuals harboring the CYP2D6*10/*10 genotype, nevertheless, there is scarce studie...