Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

• Egile Nagusiak: Evisa Gjini (Egilea), Liesbeth H. Hekking (Egilea), Axel Küchler (Egilea), Pipsa Saharinen (Egilea), Erno Wienholds (Egilea), Jan-Andries Post (Egilea), Kari Alitalo (Egilea), Stefan Schulte-Merker (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2011-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

SUMMARY Tie-2 is a member of the receptor tyrosine kinase family and is required for vascular remodeling and maintenance of mammalian vessel integrity. A number of mutations in the human TIE2 gene have been identified in patients suffering from cutaneomucosal venous malformations and ventricular sep...