Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

• Main Authors: Evisa Gjini (Author), Liesbeth H. Hekking (Author), Axel Küchler (Author), Pipsa Saharinen (Author), Erno Wienholds (Author), Jan-Andries Post (Author), Kari Alitalo (Author), Stefan Schulte-Merker (Author)
• Format: Book
• Published: The Company of Biologists, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Tie-2 is a member of the receptor tyrosine kinase family and is required for vascular remodeling and maintenance of mammalian vessel integrity. A number of mutations in the human TIE2 gene have been identified in patients suffering from cutaneomucosal venous malformations and ventricular sep...