Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

• Main Authors: Andrea Bedini (Author), Lorenzo Di Cesare Mannelli (Author), Laura Micheli (Author), Monica Baiula (Author), Gabriela Vaca (Author), Rossella De Marco (Author), Luca Gentilucci (Author), Carla Ghelardini (Author), Santi Spampinato (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potential, although relevant adverse effects have limited their clinical use. Functionally selective KOPr agonists may activate, in a pathway-specific manner, G protein-mediated signaling, that produces antino...