Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

• Main Authors: Nusrat Jahan Selsi (Author), Lira Barua (Author), Debpriya Bhattacharjee (Author), Gulamur Rahman (Author), Syeda Sakiatuz Zannat (Author), Najia Absar Munia (Author), Rubaiyat Fahad (Author), Tanjiba Harun Bipasha (Author), Azizur Rahman (Author), Raju Dash (Author)
• Format: Book
• Published: Mazandaran University of Medical Sciences, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma. The present study examined acyclovir, reported as a low-affinity PNP inhibitor, for the...