Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

• मुख्य लेखकों: Nusrat Jahan Selsi (लेखक), Lira Barua (लेखक), Debpriya Bhattacharjee (लेखक), Gulamur Rahman (लेखक), Syeda Sakiatuz Zannat (लेखक), Najia Absar Munia (लेखक), Rubaiyat Fahad (लेखक), Tanjiba Harun Bipasha (लेखक), Azizur Rahman (लेखक), Raju Dash (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Mazandaran University of Medical Sciences, 2019-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma. The present study examined acyclovir, reported as a low-affinity PNP inhibitor, for the...