Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex

• Main Authors: Yong He (Author), Yue Wang (Author), Heming Yu (Author), Yu Tian (Author), Xiangyu Chen (Author), Chong Chen (Author), Yikun Ren (Author), Zhi Chen (Author), Yi Ren (Author), Xue Gong (Author), Ke Cheng (Author), Xiaolei Liu (Author), Lianmei Zhong (Author), Yi Guo (Author), Peng Xie (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons is well understood, which can alleviate inflammation. Nevertheless, potential effects of Nr4a2 on neuroinflammation associated with d...