Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats

• Autori principali: Milne Brian (Autore), Mattioli Theresa-Alexandra M (Autore), Cahill Catherine M (Autore)
• Natura: Libro
• Pubblicazione: SAGE Publishing, 2010-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition o...