What matters for drug delivery to tumor by nanoparticles: Gaining insights from PBPK/PD simulation of drug nanocrystals

Background and purpose: In our previous studies, drug nanocrystals were directly prepared by solution crystallization, possessing uniform particle size and morphology suitable for intravenous (IV) injection. These nanocrystals accumulated in a small percentage of their injected dose in tumor-bearing...

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Main Authors: Shan Lu (Author), Clairissa Corpstein (Author), Kinam Park (Author), Tonglei Li (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2024-07-01T00:00:00Z.
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