A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model

• 主要な著者: Songmao Zheng (著者), David Polidori (著者), Yuanping Wang (著者), Brian Geist (著者), Xiefan Lin‐Schmidt (著者), Jennifer L. Furman (著者), Serena Nelson (著者), Andrea R. Nawrocki (著者), Simon A. Hinke (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2023-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐like (GFRAL) receptor expressed in the area postrema....