A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model

• Main Authors: Songmao Zheng (Author), David Polidori (Author), Yuanping Wang (Author), Brian Geist (Author), Xiefan Lin‐Schmidt (Author), Jennifer L. Furman (Author), Serena Nelson (Author), Andrea R. Nawrocki (Author), Simon A. Hinke (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐like (GFRAL) receptor expressed in the area postrema....