Variation of Two S3b Residues in KV4.1-4.3 Channels Underlies Their Different Modulations by Spider Toxin κ-LhTx-1

• Main Authors: Zhen Xiao (Author), Piao Zhao (Author), Xiangyue Wu (Author), Xiangjin Kong (Author), Ruiwen Wang (Author), Songping Liang (Author), Cheng Tang (Author), Zhonghua Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The naturally occurred peptide toxins from animal venoms are valuable pharmacological tools in exploring the structure-function relationships of ion channels. Herein we have identified the peptide toxin κ-LhTx-1 from the venom of spider Pandercetes sp (the Lichen huntsman spider) as a novel selectiv...