Targeting TIGIT for cancer immunotherapy: recent advances and future directions

• Main Authors: Peng Zhang (Author), Xinyuan Liu (Author), Zhuoyu Gu (Author), Zhongxing Jiang (Author), Song Zhao (Author), Yongping Song (Author), Jifeng Yu (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T cells, natural killer (NK) cells, regulatory T cells (Tregs), and tumor-infiltrating lymphocytes (TILs). TIGIT ha...