Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica.

• Main Authors: Sha Zhou (Author), Xin Jin (Author), Yalin Li (Author), Wei Li (Author), Xiaojun Chen (Author), Lei Xu (Author), Jifeng Zhu (Author), Zhipeng Xu (Author), Yang Zhang (Author), Feng Liu (Author), Chuan Su (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:More than 220 million people worldwide are chronically infected with schistosomes, causing severe disease or even death. The major pathological damage occurring in schistosomiasis is attributable to the granulomatous inflammatory response and liver fibrosis induced by schistosome eggs. Th...