Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells

• Main Authors: Francesco K. Touani (Author), Melanie Borie (Author), Feryel Azzi (Author), Dominique Trudel (Author), Nicolas Noiseux (Author), Shant Der Sarkissian (Author), Sophie Lerouge (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The efficacy of cell therapy is limited by low retention and survival of transplanted cells in the target tissues. In this work, we hypothesize that pharmacological preconditioning with celastrol, a natural potent antioxidant, could improve the viability and functions of mesenchymal stromal cells (M...