A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

• Main Authors: Hannah M. Jones (Author), Zhiwei Zhang (Author), Paul Jasper (Author), Haobin Luo (Author), Lindsay B. Avery (Author), Lindsay E. King (Author), Hendrik Neubert (Author), Hugh A. Barton (Author), Alison M. Betts (Author), Robert Webster (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms. To address this, we developed a mAb physiologically‐based PK model...