Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations

• Main Authors: Adrien eMoreau (Author), Dagmar I Keller (Author), Hai eHuang (Author), Véronique eFressart (Author), Christian eSchmied (Author), Quadiri eTimour (Author), Mohamed eChahine (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human cardiac sodium channel Nav1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials. Nav1.5 dysfunctions due to mutations cause cardiac diseases such as the LQT3 form of long QT syndrome, conduction disorders, and Brugada syndrome...