Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase

• Main Authors: Ahmed H. E. Hassan (Author), Yeon Il Oh (Author), Chae Hyeon Lee (Author), Yeon Ju Kim (Author), Soo Bin Cho (Author), Md. Maqusood Alam (Author), Sang-Eun Park (Author), Kyung-Sook Chung (Author), Kyung-Tae Lee (Author), Yong Sup Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phenethyl-based edelfosine-analogs with saturated, monounsaturated, or polyunsaturated alkoxy substituents on phenyl ring were designed as novel antitumor lipids modulating p38 MAPK. Evaluation of the synthesised compounds against nine panels of diverse cancer cells presented saturated and monounsat...