Notum deacylates octanoylated ghrelin

• Asıl Yazarlar: Yuguang Zhao (Yazar), Laura-Nadine Schuhmacher (Yazar), Morgan Roberts (Yazar), Satoshi Kakugawa (Yazar), Ganka Bineva-Todd (Yazar), Steve Howell (Yazar), Nicola O'Reilly (Yazar), Christine Perret (Yazar), Ambrosius P. Snijders (Yazar), Jean-Paul Vincent (Yazar), E. Yvonne Jones (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2021-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objectives: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...