Notum deacylates octanoylated ghrelin

• Main Authors: Yuguang Zhao (Author), Laura-Nadine Schuhmacher (Author), Morgan Roberts (Author), Satoshi Kakugawa (Author), Ganka Bineva-Todd (Author), Steve Howell (Author), Nicola O'Reilly (Author), Christine Perret (Author), Ambrosius P. Snijders (Author), Jean-Paul Vincent (Author), E. Yvonne Jones (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...