Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy

• Main Authors: Sujie Huang (Author), Yuxuan Gao (Author), Ling Ma (Author), Bo Jia (Author), Wenhao Zhao (Author), Yufan Yao (Author), Wenyuan Li (Author), Tongyi Lin (Author), Rui Wang (Author), Jingjing Song (Author), Wei Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its significant toxicity seriously hampers its application in tumor therapy. In this study, we developed novel melittin analogs with pH-responsive, cell-penetrating and membrane-lytic activities by replacing ar...