Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy

• Hauptverfasser: Sujie Huang (Verfasst von), Yuxuan Gao (Verfasst von), Ling Ma (Verfasst von), Bo Jia (Verfasst von), Wenhao Zhao (Verfasst von), Yufan Yao (Verfasst von), Wenyuan Li (Verfasst von), Tongyi Lin (Verfasst von), Rui Wang (Verfasst von), Jingjing Song (Verfasst von), Wei Zhang (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2024-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its significant toxicity seriously hampers its application in tumor therapy. In this study, we developed novel melittin analogs with pH-responsive, cell-penetrating and membrane-lytic activities by replacing ar...