Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy
Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its significant toxicity seriously hampers its application in tumor therapy. In this study, we developed novel melittin analogs with pH-responsive, cell-penetrating and membrane-lytic activities by replacing ar...
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Elsevier,
2024-02-01T00:00:00Z.
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