In Silico Exploration of Aryl Halides Analogues as CheckpointKinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study,and ADMET Screening

• Main Authors: Adib Ghaleb (Author), Adnane Aouidate (Author), Mohammed Bouachrine (Author), Tahar Lakhlifi (Author), Abdelouhid Sbai (Author)
• Format: Knjiga
• Izdano: Tabriz University of Medical Sciences, 2019-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint kinase1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop modelswith good predictive ability, highlight the important interactions between the ligand and theChk1 receptor...