Quantitative pulmonary pharmacokinetics of tetrandrine for SARS-CoV-2 repurposing: a physiologically based pharmacokinetic modeling approach

• Main Authors: Furun Wang (Author), Liuhan Dong (Author), Juanwen Hu (Author), Shijie Yang (Author), Lingchao Wang (Author), Zhiwei Zhang (Author), Wenpeng Zhang (Author), Xiaomei Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetrandrine (TET) has been traditionally used in China as a medication to treat silicosis and has recently demonstrated anti-SARS-CoV-2 potential in vitro. By recognizing the disparity between in vitro findings and in vivo performance, we aimed to estimate the free lung concentration of TET using a...