Vaccination with the Surface Proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans Induces Antibodies but Fails to Provide Protection against Buruli Ulcer.

• Main Authors: Miriam Bolz (Author), Angèle Bénard (Author), Anita M Dreyer (Author), Sarah Kerber (Author), Andrea Vettiger (Author), Wulf Oehlmann (Author), Mahavir Singh (Author), Malcolm S Duthie (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a chronic ulcerative neglected tropical disease of the skin and subcutaneous tissue that is most prevalent in West African countries. M. ulcerans produces a cytotoxic macrolide exotoxin called mycolactone, which causes exte...