Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay

• Main Authors: Jingrong Zhao (Author), Zhelin Li (Author), Ruchira Puri (Author), Kelvin Liu (Author), Israel Nunez (Author), Liang Chen (Author), Sika Zheng (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonsense-mediated mRNA decay (NMD) degrades transcripts with premature stop codons. Given the prevalence of nonsense single nucleotide polymorphisms (SNPs) in the general population, it is urgent to catalog the effects of clinically approved drugs on NMD activity: any interference could alter the ex...